Cytovia Therapeutics: An NK Revolution Towards a Cancer Cure
Cytovia Therapeutics aims to accelerate patient access to transformational cell therapies and immunotherapies, addressing several of the most challenging unmet medical needs in cancer. Cytovia focuses on harnessing the innate immune system by developing complementary and disruptive NK-cell and NK-engager antibody platforms. We are developing three types of iPSC-derived Natural Killer cells: unedited iNK cells, TALEN® gene-edited iNK cells with improved function and persistence, and TALEN® gene-edited iNK cells with chimeric antigen receptors (CAR-iNKs) to improve tumor-specific targeting. The second complementary cornerstone technology is a quadrivalent multispecific antibody platform designed to engage natural killer cells by targeting NKp46 using a proprietary Flex-NK™ technology. These two technology platforms are being used to develop treatment of patients with solid tumors such as hepatocellular carcinoma (HCC) and glioblastoma as well as hematological malignancies such as refractory multiple myeloma. Clinical studies are expected to initiate in 2022. Cytovia’s R&D laboratories in Natick, MA and GMP cell manufacturing facility in Puerto Rico are augmented by scientific partnerships with Cellectis, CytoImmune, the Hebrew University of Jerusalem, INSERM, the New York Stem Cell Foundation, the National Cancer Institute, and the University of California San Francisco (UCSF). Cytovia Therapeutics has recently formed CytoLynx Therapeutics, a joint-venture entity focused on research and development, manufacturing, and commercialization activities in Greater China and beyond. Find out more at www.cytoviatx.com.
Induced Pluripotent Stem Cells: Optimal Starting Material for the Manufacturing of Our NK Cells
Cytovia Therapeutics Chief Medical Officer Stanley R. Frankel, MD, Chief Scientific Officer Wei Li, PhD, and VP, Cell Therapy Nejmi Dilmac, PhD discuss the use of induced pluripotent stem cells (iPSCs) as the foundational building block for the development of our highly-scalable, genetically-engineered iNK cells, and the advantage this provides as opposed to other approaches such as donor-derived cells.
Our Dual Platform Advantage: Combining iNK Cells and Flex-NK™ Cell Engagers
Cytovia Therapeutics Chief Medical Officer Stanley R. Frankel, MD, Chief Scientific Officer Wei Li, PhD, and VP, Cell Therapy Nejmi Dilmac, PhD discuss how Flex-NK™ therapies activate and redirect both endogenous and allogeneic NK cells, inducing increased cytotoxicity towards tumor cells. Cytovia is the first company to develop both its own NK cell and multispecific antibody platforms.